Drug Information

Drug General Information
Drug ID
D0U2CB
Former ID
DNC011692
Drug Name
Ibuproxam
Drug Type
Small molecular drug
Indication Respiratory disease [ICD10:J00-J99] Withdrawn from market [533573]
Formula
C13H19NO2
Canonical SMILES
CC(C)CC1=CC=C(C=C1)C(C)C(=O)NO
InChI
1S/C13H19NO2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(15)14-16/h4-7,9-10,16H,8H2,1-3H3,(H,14,15)
InChIKey
BYPIURIATSUHDW-UHFFFAOYSA-N
PubChem Compound ID
68704
SuperDrug ATC ID
M01AE13
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [533474]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 533573Anti-inflammatory agents: determination of ibuproxam and its metabolite humans. Correlation between bioavailability, tolerance and chemico-physical characteristics. Arzneimittelforschung. 1980;30(9):1607-9.
Ref 533474J Med Chem. 1987 Nov;30(11):2121-6.In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase.

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