Drug Information

Drug General Information
Drug ID
D01YGY
Former ID
DIB012081
Drug Name
UC-1011
Synonyms
UC-1011; UC-2021; UC-2025; GABA A receptor antagonists (Alzheimer's disease); GABA A receptor antagonists (Alzheimer's disease), Umecrine; 3beta-20beta-dihydroxy-5alpha-pregnane; 3beta-20beta-dihydroxy-5alpha-pregnane (Alzheimer's disease), Umecrine
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Investigative [543814]
Company
Umecrine AB
Canonical SMILES
[C@@]12([C@H]([C@H]3[C@@H]([C@@]4([C@@H](CC3)C[C@H](CC4<br />)O)C)CC2)CC[C@@H]1[C@@H](O)C)C
Target and Pathway
Target(s) GABA A receptor Target Info Antagonist [543814]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 543814(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
Ref 543814(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).

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