Drug Information

Drug General Information
Drug ID
D0C5XF
Former ID
DIB008914
Drug Name
GSK-1344386B
Synonyms
CCR2 antagonist (atherosclerosis); GSK-1344386B; CCR2 antagonist (atherosclerosis), GlaxoSmithKline
Indication Atherosclerosis [ICD9: 414.0, 440; ICD10:I70] Investigative [543887]
Company
GlaxoSmithKline plc
Canonical SMILES
C12(CNc3c2ccc(c3)Cl)CCN(C[C@H]1O)C[C@H](C1CCN(CC1)C(=O)<br />/C=C/c1cc(cc(c1)F)F)O
Target and Pathway
Target(s) C-C chemokine receptor type 2 Target Info Antagonist [543887]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Defensins
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543887(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 59).
Ref 543887(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 59).

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