Drug Information

Drug General Information
Drug ID
D03CHA
Former ID
DIB011968
Drug Name
CB1 antagonists
Synonyms
CB1 antagonists (metabolic syndrome); CB1 antagonists (metabolic syndrome), Esteve
Indication Metabolic disorders [ICD9: 270-279; ICD10:E70-E89] Investigative [552166]
Company
Esteve
Canonical SMILES
c1(ccc(cc1Cl)Cl)N1[C@@H]([C@@H](C(=N1)C(=O)NN1[C@@H](CC<br />C[C@@H]1C)C)C)c1ccc(cc1)Cl.Cl
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Antagonist [543877]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 552166WO patent application no. 2005020992, NOVEL MEDICAL USE OF SELECTIVE CB1-RECEPTOR ANTAGONISTS.
Ref 543877(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56).

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