Drug Information

Drug General Information
Drug ID
D0V5LJ
Former ID
DIB016512
Drug Name
JNJ-10329670
Synonyms
Cathepsin S inhibitors (autoimmune disease); JNJ-10329670; Cathepsin S inhibitors (autoimmune disease), J&J PRD; Cathepsin S inhibitors (autoimmune disease), Johnson & Johnson
Drug Type
Small molecular drug
Indication Autoimmune diabetes [ICD10:E08-E13] Investigative [543601]
Company
Johnson & Johnson Pharmaceutical Research & Development LLC
Formula
C30H34ClF3N6O3S
Canonical SMILES
C1CCCN1C(=O)CSc1c(C(F)(F)F)ccc(c1)c1c2CN(CCc2n(CC(CN2CC<br />C(CC2)C)O)n1)C(=O)C
PubChem Compound ID
10168449
Target and Pathway
Target(s) Cathepsin S Target Info Inhibitor [543601]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Tuberculosis
NetPath Pathway Leptin Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways Class I MHC mediated antigen processing & presentation
Trafficking and processing of endosomal TLR
References
Ref 543601(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2353).
Ref 543601(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2353).

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