Drug Information

Drug General Information
Drug ID
D07DNV
Former ID
DIB007457
Drug Name
ARN-2966
Synonyms
ARN-2966; ARN-4261; Abeta aggregation inhibitors (Alzheimer's disease); Abeta aggregation inhibitors (Alzheimer's disease), New York University/Aria Neurosciences
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Investigative [542536]
Company
New York University
Formula
C12H12N2O
InChI
InChI=1S/C12H12N2O/c15-12-7-2-1-6-11(12)14-9-10-5-3-4-8-13-10/h1-8,14-15H,9H2
InChIKey
GXJRVWZNMZGWAQ-UHFFFAOYSA-N
PubChem Compound ID
14936865
PubChem Substance ID
54132411, 124398717, 128020164, 136350089, 187051831, 210275734, 210281395, 216587116, 236130105, 252450120, 252480477, 252543640
Target and Pathway
Target(s) Amyloid beta A4 protein Target Info Inhibitor [543619]
KEGG Pathway Notch signaling pathway
Alzheimer's disease
Reactome Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
EPH-ephrin mediated repulsion of cells
WikiPathways Notch Signaling Pathway
Signaling by ERBB4
Signaling by NOTCH3
Signaling by NOTCH4
Signaling by NOTCH1
Signaling by NOTCH2
Notch Signaling Pathway
Alzheimers Disease
Signalling by NGF
References
Ref 542536(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7530).
Ref 543619(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402).

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