Drug Information

Drug General Information
Drug ID
D0T0BS
Former ID
DIB000577
Drug Name
CGS-18102A
Synonyms
CGP-50281; CGS-18102
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Terminated [545030]
Company
Novartis AG
Formula
C16H24ClNO2
Canonical SMILES
[C@H]12c3c(OC[C@@H]1N(CCC2)CCC)cccc3OC.Cl
CAS Number
CAS 100746-36-9
PubChem Compound ID
146963
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Modulator [526784]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 545030Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001927)
Ref 526784Quantitative determination of CGS 18102A, a new anxiolytic, in human plasma using capillary gas chromatography/mass spectrometry. Biomed Chromatogr. 1992 Sep-Oct;6(5):244-7.

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