Drug Information

Drug General Information
Drug ID
D0B9OG
Former ID
DIB005977
Drug Name
Adipiplon
Synonyms
GABA modulator (insomnia), Neurogen; NG-2-73
Drug Type
Small molecular drug
Indication Sleep disorders [ICD9: 307.4, 327, 780.5; ICD10:F51, G47] Phase 2 [522324]
Company
Neurogen Corporation
Formula
C18H18FN7
Canonical SMILES
c1n2c(c(c(n1)Cn1c(ncc1)c1c(cccn1)F)CCC)nc(n2)C
CAS Number
CAS 840486-93-3
PubChem Compound ID
11198924
Target and Pathway
Target(s) Gamma-aminobutyric-acid receptor alpha-3 subunit Target Info Modulator [531560]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 522324ClinicalTrials.gov (NCT00683436) Efficacy and Safety Study of Adipiplon, Placebo and an Active Control in Primary Insomniacs. U.S. National Institutes of Health.
Ref 531560Discriminative stimulus properties of GABAA receptor positive allosteric modulators TPA023, ocinaplon and NG2-73 in rats trained to discriminate chlordiazepoxide or zolpidem. Eur J Pharmacol. 2011 Oct 1;668(1-2):190-3.

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