Drug Information

Drug General Information
Drug ID
D04TQT
Former ID
DIB014463
Drug Name
Barusiban
Synonyms
FE-200440
Drug Type
Small molecular drug
Indication Androgen decline [ICD10:E20-E35] Phase 2 [521712]
Company
Ferring Pharmaceuticals Inc
Formula
C40H63N9O8S
Canonical SMILES
N1C(=O)[C@@H](NC(=O)[C@H](NC(=O)CCSCC[C@H](NC(=O)[C@@H]<br />(NC(=O)[C@@H]1[C@@H](CC)C)CC(=O)N)C(=O)N([C@H](CO)CCCN)<br />C)Cc1c[nH]c2c1cccc2)[C@H](CC)C
CAS Number
CAS 285571-64-4
PubChem Compound ID
44149146
Target and Pathway
Target(s) Oxytocin receptor Target Info Antagonist [530031]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Oxytocin signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Oxytocin receptor mediated signaling pathway
Reactome Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Myometrial Relaxation and Contraction Pathways
Oxytocin signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 521712ClinicalTrials.gov (NCT00209326) A Proof of Concept Study Assessing the Effect of Four Different Single Bolus Intravenous Doses of FE200440 and Placebo on Stopping Preterm Labor. U.S. National Institutes of Health.
Ref 530031The effect of barusiban, a selective oxytocin antagonist, in threatened preterm labor at late gestational age: a randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol. 2009 Jun;200(6):627.e1-10.

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