Drug Information

Drug General Information
Drug ID
D04GSV
Former ID
DNC012881
Drug Name
TRICIRIBINE
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1/2 [524080], [541208]
Formula
C13H16N6O4
InChI
InChI=1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)
InChIKey
HOGVTUZUJGHKPL-UHFFFAOYSA-N
PubChem Compound ID
290486
PubChem Substance ID
433272, 7536840, 8137167, 10319591, 11405486, 26758185, 34830899, 48020051, 57401183, 75128850, 85787232, 92764035, 99302615, 103145651, 104484119, 117619685, 125824212, 126483830, 128089449, 144224089, 162023335, 163688643, 175607388, 178102543, 179236156, 226442964, 242487231
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) HIV-1 reverse transcriptase Target Info Inhibitor [527570]
References
Ref 524080ClinicalTrials.gov (NCT01697293) Triciribine Phosphate in Breast Cancer. U.S. National Institutes of Health.
Ref 541208(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5920).
Ref 527570J Med Chem. 2005 Jun 2;48(11):3840-51.Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-methyl-1-(beta-D-ribofuranosyl)- and 3-amino-5-methyl-1-(2-deoxy-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,7,8-hexaazaacenaphthylene as analogues of triciribine.

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