Drug Information

Drug General Information
Drug ID
D0D7QO
Former ID
DIB013991
Drug Name
Phenylephrine hydrochloride gel
Synonyms
Incostop; Phenylephrine hydrochloride; Phenylephrine hydrochloride gel (fecal incontinence); VEN-308; Phenylephrine hydrochloride gel (fecal incontinence), SLA Pharma/Ventrus Biosciences; 10% phenylephrine HCl cream, Solvay/SLA Pharma; 20% phenylephrine HCl cream, Solvay/SLA Pharma
Indication Fecal incontinence [ICD10:R15] Approved [547809]
Company
SLA Pharma UK Ltd
Canonical SMILES
c1(cc(O)ccc1)[C@@H](O)CNC.Cl
CAS Number
CAS 61-76-7
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Modulator [527269]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 547809Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019494)
Ref 527269Effects of topically instilled bunazosin, an alpha1-adrenoceptor antagonist, on constrictions induced by phenylephrine and ET-1 in rabbit retinal arteries. Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4041-8.

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