Drug Information

Drug General Information
Drug ID
D0B2WK
Former ID
DCL000275
Drug Name
Ifetroban sodium
Synonyms
Ifetroban sodium [USAN]; BMS-180291 sodium salt; BMS-180291-02
Drug Type
Small molecular drug
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Phase 2 [539284]
Company
Bristol-Myers Squibb
Formula
C25H32N2O5
InChI
InChI=1S/C25H32N2O5/c1-2-3-6-13-26-24(30)19-15-31-25(27-19)23-18(20-10-11-21(23)32-20)14-17-8-5-4-7-16(17)9-12-22(28)29/h4-5,7-8,15,18,20-21,23H,2-3,6,9-14H2,1H3,(H,26,30)(H,28,29)/t18-,20-,21+,23-/m0/s1
InChIKey
BBPRUNPUJIUXSE-DXKRWKNPSA-N
PubChem Compound ID
3037233
PubChem Substance ID
14857086, 15477703, 23927572, 32961564, 50070824, 50831753, 53790268, 111643066, 135650374, 135928070, 179149926, 198946718, 226415543, 242651863
Target and Pathway
Target(s) Thromboxane A2 receptor Target Info Antagonist [536029]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539284(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1987).
Ref 536029AT-1 receptor antagonism modifies the mediation of endothelin-1, thromboxane A2, and catecholamines in the renal constrictor response to angiotensin II. Kidney Int Suppl. 2005 Jan;(93):S3-9.

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