Drug Information

Drug General Information
Drug ID
D0E6SB
Former ID
DIB013438
Drug Name
HQK-1001
Synonyms
Sodium ST-20; Hematological disease therapeutic (oral), HemaQuest
Drug Type
Small molecular drug
Indication Beta thalassemia [ICD10:D56.1] Phase 2 [525404]
Company
Hemaquest pharmaceuticals
Formula
C6H11NaO2
Canonical SMILES
CCC(C)(C)C(=O)[O-].[Na+]
InChI
1S/C6H12O2.Na/c1-4-6(2,3)5(7)8;/h4H2,1-3H3,(H,7,8);/q;+1/p-1
InChIKey
OOPXYEYPPHJHSE-UHFFFAOYSA-M
PubChem Compound ID
53247304
PubChem Substance ID
124363624, 124963053, 142349127, 172648310, 176270357, 198954263, 227412518
Target and Pathway
Target(s) Hemoglobin Target Info Inducer [532549]
KEGG Pathway African trypanosomiasis
Malaria
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Scavenging of heme from plasma
WikiPathways Binding and Uptake of Ligands by Scavenger Receptors
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
Factors involved in megakaryocyte development and platelet production
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 525404A phase 2 trial of HQK-1001 in HbE-beta thalassemia demonstrates HbF induction and reduced anemia. Blood. 2014 Mar 20;123(12):1956-7.
Ref 532549A phase 2 study of HQK-1001, an oral fetal haemoglobin inducer, in beta-thalassaemia intermedia. Br J Haematol. 2014 Feb;164(3):456-8.

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