Drug Information

Drug General Information
Drug ID
D00YBW
Former ID
DIB001905
Drug Name
OXY-111A
Synonyms
OXYRENS; Myo-inositol trispyrophosphate; Oxyren (oxygen release enhancer) haemoglobin-oxygen affinity allosteric modulators (Cardiovascular disease/cancer), NormOxys
Indication Cardiovascular disorder [ICD10:I00-I99] Phase 1/2 [525298]
Company
NormOxys Inc
Canonical SMILES
[C@H]12[C@H](OP(=O)(OP(=O)(O1)O)O)[C@@H]1[C@@H]([C@@H]3<br />[C@@H]2OP(=O)(OP(=O)(O3)O)O)OP(=O)(OP(=O)(O1)O)O
Target and Pathway
Target(s) Hemoglobin Target Info Enhancer [534711]
KEGG Pathway African trypanosomiasis
Malaria
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Scavenging of heme from plasma
WikiPathways Binding and Uptake of Ligands by Scavenger Receptors
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
Factors involved in megakaryocyte development and platelet production
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 525298ClinicalTrials.gov (NCT02528526) Effects of OXY111A in Primary and Secondary Hepato-Pancreato-Biliary Neoplasm.
Ref 534711Modulating the oxygen affinity of human fetal haemoglobin with synthetic allosteric modulators. Br J Haematol. 1998 Sep;102(5):1165-71.

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