Drug Information

Drug General Information
Drug ID
D0Y1GJ
Former ID
DIB012646
Drug Name
MLN-576
Synonyms
XR-11576
Indication Acute lymphoblastic leukemia [ICD9: 204.0, 556; ICD10:C91.0] Phase 1 [526301]
Company
Xenova Group plc
Canonical SMILES
n1c2c(C(=O)N[C@@H](CN(C)C)C)cccc2nc2c1c1c(cc2)c(OC)ccc1
CAS Number
CAS 346689-77-8
Target and Pathway
Target(s) Toposisomerase-1 Target Info Modulator [526301]
DNA topoisomerase II Target Info Modulator [526301]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 526301In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II. Anticancer Drugs. 2002 Jan;13(1):15-28.
Ref 526301In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II. Anticancer Drugs. 2002 Jan;13(1):15-28.

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