Drug Information

Drug General Information
Drug ID
D0G4YZ
Former ID
DIB005471
Drug Name
11C-PBR-28
Synonyms
Radiolabeled benzodiazepine receptor ligands, NIH; Carbon-11-PBR-101; Carbon-11-PBR-28; Fluorine-18-PBR-06; 11C-PBR-01; 18F-PBR-06
Indication Brain diseases [ICD10:G00-G99] Phase 2 [525281]
Company
National Institutes of Health
Canonical SMILES
n1ccc(c(c1)N(Cc1c(cccc1)O[11CH3])C(=O)C)Oc1ccccc1
Target and Pathway
Target(s) Peripheral-type benzodiazepine receptor Target Info Binder [528547]
KEGG Pathway Neuroactive ligand-receptor interaction
HTLV-I infection
References
Ref 525281ClinicalTrials.gov (NCT02513589) Molecular Imaging of Inflammation With 18F-PBR06 to Identify Unstable Carotid Plaques in Patients With Stroke.
Ref 528547PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat. Neurosci Lett. 2007 Jan 16;411(3):200-5. Epub 2006 Nov28.

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