Drug Information

Drug General Information
Drug ID
D00JRD
Former ID
DIB002812
Drug Name
PGF2ALPHA-IE
Synonyms
Prostaglandin F2alpha isopropyl ester; (5Z,9alpha,11alpha,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid isopropyl ester
Drug Type
Small molecular drug
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Phase 3 [533334]
Formula
C23H40O5
Canonical SMILES
CCCCCC(C=CC1C(CC(C1CC=CCCCC(=O)OC(C)C)O)O)O
InChI
1S/C23H40O5/c1-4-5-8-11-18(24)14-15-20-19(21(25)16-22(20)26)12-9-6-7-10-13-23(27)28-17(2)3/h6,9,14-15,17-22,24-26H,4-5,7-8,10-13,16H2,1-3H3/b9-6-,15-14+/t18-,19+,20+,21-,22+/m0/s1
InChIKey
FPABVZYYTCHNMK-YNRDDPJXSA-N
CAS Number
CAS 53764-90-2
PubChem Compound ID
5283077
PubChem Substance ID
4266010, 11038732, 14903401, 39316493, 50716500, 57358839, 113859024, 121379624, 135030673, 179656239, 184585732, 241093939, 252378183, 252457453, 252469083
Target and Pathway
Target(s) Prostaglandin F2-alpha receptor Target Info Modulator [533620], [551871]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 533334The effect of prostaglandin F2 alpha-1-isopropylester (PGF2 alpha-IE) on uveoscleral outflow. Prog Clin Biol Res. 1989;312:429-36.
Ref 533620Role of nitric oxide in PGF2 alpha-induced ocular hyperemia. Exp Eye Res. 1994 Oct;59(4):401-7.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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