Drug Information

Drug General Information
Drug ID
D02HBW
Former ID
DIB012744
Drug Name
SCH-32615
Synonyms
(S)-N-[N-(1-Carboxy-2-phenylethyl)-L-phenylalanyl]-beta-alanine; 83861-02-3
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Discontinued in Phase 2 [545185]
Formula
C21H24N2O5
Canonical SMILES
C1=CC=C(C=C1)CC(C(=O)NCCC(=O)O)NC(CC2=CC=CC=C2)C(=O)O
InChI
1S/C21H24N2O5/c24-19(25)11-12-22-20(26)17(13-15-7-3-1-4-8-15)23-18(21(27)28)14-16-9-5-2-6-10-16/h1-10,17-18,23H,11-14H2,(H,22,26)(H,24,25)(H,27,28)/t17-,18-/m0/s1
InChIKey
WOVRTBFSWOVRST-ROUUACIJSA-N
CAS Number
CAS 83861-02-3
PubChem Compound ID
5486715
PubChem Substance ID
11694095, 14902662, 39472811, 50065288, 57364119, 79496405, 103417081, 103928134, 113994136, 129612559, 135258037, 143286999, 226720688
Target and Pathway
Target(s) Neutral endopeptidase Target Info Inhibitor [531695], [531869]
KEGG Pathway Renin-angiotensin system
Hematopoietic cell lineage
Protein digestion and absorption
Alzheimer's disease
NetPath Pathway EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways Metabolism of Angiotensinogen to Angiotensins
Primary Focal Segmental Glomerulosclerosis FSGS
Alzheimers Disease
References
Ref 545185Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002402)
Ref 531695The antinociceptive effects of SCH-32615, a neutral endopeptidase (enkephalinase) inhibitor, microinjected into the periaqueductal, ventral medulla and amygdala. Brain Res. 1990 Jun 18;520(1-2):123-30.
Ref 531869The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans. Life Sci. 2012 Oct 15;91(13-14):743-8.

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