Drug Information

Drug General Information
Drug ID
D0H6PN
Former ID
DIB006078
Drug Name
LORECLEZOLE
Synonyms
BAN; Loreclezole < Rec INN; R-72063; (Z)-1-(alpha,2,4-Trichlorostyryl)-1H-1,2,4-triazole; (Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)vinyl]-1H-1,2,4-triazole
Drug Type
Small molecular drug
Indication Epileptic seizures [ICD9: 345.9, 780.3; ICD10:G40, P90, R56] Discontinued in Phase 2 [540868], [546397]
Formula
C10H6Cl3N3
InChI
InChI=1S/C10H6Cl3N3/c11-7-1-2-8(9(12)3-7)10(13)4-16-6-14-5-15-16/h1-6H/b10-4-
InChIKey
XGLHZTBDUXXHOM-WMZJFQQLSA-N
CAS Number
CAS 117857-45-1
PubChem Compound ID
3034012
PubChem Substance ID
10047882, 11114016, 12014336, 15368627, 36077812, 47206590, 50064223, 51325336, 57352840, 81065616, 111635574, 135028790, 137241798, 140375852, 160682529, 178102116, 179322581, 184526471, 198985978, 223554778, 226874733, 250095725
Target and Pathway
Target(s) GABA A receptor Target Info Modulator [534346]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 540868(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5466).
Ref 546397Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007906)
Ref 534346Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60.

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