Drug Information

Drug General Information
Drug ID
D03LAB
Former ID
DIB010931
Drug Name
TBC-3711
Synonyms
N-(2-Acetyl-4,6-dimethylphenyl)-3-[N-(3,4-dimethylisoxazol-5-yl)sulfamoyl]thiophene-2-carboxamide
Drug Type
Small molecular drug
Indication Hypotension [ICD9: 458, 796.3; ICD10:I95] Phase 2 [521781]
Company
Encysive Pharmaceuticals
Formula
C20H21N3O5S2
Canonical SMILES
CC1=CC(=C(C(=C1)C(=O)C)NC(=O)C2=C(C=CS2)S(=O)(=O)NC3=C(<br />C(=NO3)C)C)C
InChI
1S/C20H21N3O5S2/c1-10-8-11(2)17(15(9-10)14(5)24)21-19(25)18-16(6-7-29-18)30(26,27)23-20-12(3)13(4)22-28-20/h6-9,23H,1-5H3,(H,21,25)
InChIKey
IAYNHDZSSDUYHY-UHFFFAOYSA-N
CAS Number
CAS 374680-51-0
PubChem Compound ID
9911482
PubChem Substance ID
14881851, 24191792, 45983140, 53787572, 74991468, 85210261, 103250757, 104032953, 135263165, 137233872, 143004164, 228849640, 244797026
Target and Pathway
Target(s) Endothelin-1 receptor Target Info Antagonist [526125]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Renin secretion
Pathways in cancer
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Endothelin signaling pathway
Pathway Interaction Database Endothelins
EGFR-dependent Endothelin signaling events
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 521781ClinicalTrials.gov (NCT00272961) A Study Of Different Doses Of TBC3711 In Patients With Uncontrolled High Blood Pressure Already Taking Medications For High Blood Pressure.. U.S. National Institutes of Health.
Ref 526125TBC3711, an ET(A) receptor antagonist, reduces neonatal hypoxia-induced pulmonary hypertension in piglets. Pediatr Res. 2001 Sep;50(3):374-83.

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