Drug Information

Drug General Information
Drug ID
D06ZVC
Former ID
DNC007865
Drug Name
WAY-181187
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Discontinued in Phase 1 [540213], [548017]
Formula
C15H13ClN4O2S2
InChI
InChI=1S/C15H13ClN4O2S2/c16-13-14(19-7-8-23-15(19)18-13)24(21,22)20-9-10(5-6-17)11-3-1-2-4-12(11)20/h1-4,7-9H,5-6,17H2
InChIKey
RYBOXBBYCVOYNO-UHFFFAOYSA-N
PubChem Compound ID
10150497
PubChem Substance ID
15142618, 22550257, 40134673, 49689430, 57374276, 76060246, 103540481, 134345070, 137144127, 143230484, 162224464, 163642457, 172919869, 178100291, 198986553, 227080072, 248096861
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540213(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3240).
Ref 548017Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021227)

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