Drug Information

Drug General Information
Drug ID
D0W9NO
Former ID
DIB013788
Drug Name
YT-146
Synonyms
Adenosine A2 agonists, Yamasa
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Phase 2 [544864]
Company
Yamasa Shoyu Co Ltd
Formula
C18H25N5O4
Canonical SMILES
n1(c2c(nc1)c(nc(n2)C#CCCCCCC)N)[C@H]1[C@@H]([C@@H]([C@H<br />](O1)CO)O)O
CAS Number
CAS 90596-75-1
PubChem Compound ID
146207
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Agonist [533910]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 544864Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001363)
Ref 533910Identification of adenosine A2 receptor-cAMP system in human aortic endothelial cells. Biochem Biophys Res Commun. 1994 Mar 15;199(2):905-10.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.