Drug Information

Drug General Information
Drug ID
D01VAP
Former ID
DIB010738
Drug Name
YM-430
Synonyms
YM-15430-1; YM-15430-2; YM-15430-3; YM-15430-4
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Phase 2 [534350]
Company
Yamanouchi Pharmaceutical Co Ltd
Canonical SMILES
C1(=C(NC(=C([C@H]1c1cc([N+](=O)[O-])ccc1)C(=O)OCCCCNC[C<br />@@H](COc1ccccc1)O)C)C)C(=O)OC
CAS Number
CAS 153192-22-4
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Modulator [534350]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 534350Cardiovascular effects of YM430, a 1,4-dihydropyridine derivative with beta-adrenoceptor blocking activity, in dogs and rats. Biol Pharm Bull. 1997 Mar;20(3):230-6.
Ref 534350Cardiovascular effects of YM430, a 1,4-dihydropyridine derivative with beta-adrenoceptor blocking activity, in dogs and rats. Biol Pharm Bull. 1997 Mar;20(3):230-6.

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