Drug Information

Drug General Information
Drug ID
D0XK0T
Former ID
DNC001508
Drug Name
WAY 100135
Drug Type
Small molecular drug
Indication Discovery agent Terminated [542821], [545080]
Formula
C24H33N3O2
InChI
InChI=1S/C24H33N3O2/c1-24(2,3)25-23(28)20(19-10-6-5-7-11-19)18-26-14-16-27(17-15-26)21-12-8-9-13-22(21)29-4/h5-13,20H,14-18H2,1-4H3,(H,25,28)/t20-/m1/s1
InChIKey
UMTDAKAAYOXIKU-HXUWFJFHSA-N
CAS Number
CAS 133025-23-7
PubChem Compound ID
6604840
PubChem Substance ID
11113999, 11646520, 15253366, 43224578, 78007710, 103212376, 103978073, 114638095, 129390640, 134349875, 135651319, 135694995, 136350341, 137128031, 223621316, 230047400
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Antagonist [538050]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 542821(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 79).
Ref 545080Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002060)
Ref 538050Influence of 5-HT1A receptor antagonism on plus-maze behaviour in mice. II. WAY 100635, SDZ 216-525 and NAN-190. Pharmacol Biochem Behav. 1997 Oct;58(2):593-603.

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