Drug Information

Drug General Information
Drug ID
D06GNF
Former ID
DIB010651
Drug Name
TS-022
Synonyms
Prostaglandin derivative (topical, dermatitis), Taisho
Indication Atopic dermatitis [ICD9: 691.8, 692.9; ICD10:L00-L99] Phase 2 [522686]
Company
Taisho Pharmaceutical Co Ltd
Canonical SMILES
[C@@H]1([C@@H]([C@H]([C@@H](C1)Cl)CCCCSCC(=O)O)C#C[C@H]<br />(C1CCCCC1)O)O
CAS Number
CAS 170730-17-3
Target and Pathway
Target(s) Prostaglandin D2 receptor Target Info Agonist [528554]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 522686ClinicalTrials.gov (NCT00914186) Study of TS-022 in Adult Patients With Atopic Dermatitis With Pruritus (POC). U.S. National Institutes of Health.
Ref 528554Effects of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritus, cutaneous barrier disruptions and atopic dermatitis in mice. Eur J Pharmacol. 2007 Feb 5;556(1-3):207-14. Epub 2006 Nov 3.

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