Drug Information

Drug General Information
Drug ID
D03JSS
Former ID
DIB011479
Drug Name
Tidembersat
Synonyms
SB-218842
Drug Type
Small molecular drug
Indication Migraine [ICD9: 346; ICD10:G43] Discontinued in Phase 1 [546798]
Company
SmithKline Beecham plc
Formula
C20H19F2NO4
Canonical SMILES
[C@@H]1(c2c(OC([C@@H]1O)(C)C)ccc(c2)C(=O)C)NC(=O)c1cc(c<br />c(c1)F)F
CAS Number
CAS 175013-73-7
PubChem Compound ID
170378
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Antagonist [551730]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 546798Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010348)
Ref 551730Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75.

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