Drug Information

Drug General Information
Drug ID
D06MPF
Former ID
DIB009200
Drug Name
Sch-40120
Drug Type
Small molecular drug
Indication Pruritus [ICD9: 698; ICD10:L29] Terminated [545555]
Company
Schering-Plough Corp
Formula
C18H15ClN2O
Canonical SMILES
n1(c2c(c(=O)c3c1CCCC3)cccn2)c1cc(Cl)ccc1
CAS Number
CAS 110545-79-4
PubChem Compound ID
3081026
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Modulator [526810]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 545555Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003693)
Ref 526810Actions of a 5-lipoxygenase inhibitor, Sch 40120, on acute inflammatory responses. J Pharmacol Exp Ther. 1992 Aug;262(2):721-8.

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