Drug Information

Drug General Information
Drug ID
D0U5EU
Former ID
DIB007053
Drug Name
SC-45662
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [544863]
Company
GD Searle & Co
Formula
C20H32O4S
Canonical SMILES
c1(c(C(C)(C)C)cc(S[C@@H]([C@H](OCC(=O)O)C)C)cc1C(C)(C)C<br />)O
CAS Number
CAS 135133-84-5
PubChem Compound ID
9799427
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [528836]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 544863Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001362)
Ref 528836The immunosuppressive properties of enisoprost and a 5-lipoxygenase inhibitor (SC-45662). Transplantation. 1991 Dec;52(6):1053-7.

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