Drug Information

Drug General Information
Drug ID
D05GOM
Former ID
DIB000570
Drug Name
S-20928
Drug Type
Small molecular drug
Indication Sleep disorders [ICD9: 307.4, 327, 780.5; ICD10:F51, G47] Terminated [538838], [546213]
Company
Servier
Formula
C17H19NO
InChI
InChI=1S/C17H19NO/c19-17(15-8-4-9-15)18-12-11-14-7-3-6-13-5-1-2-10-16(13)14/h1-3,5-7,10,15H,4,8-9,11-12H2,(H,18,19)
InChIKey
GLXSBZGTGMPDKH-UHFFFAOYSA-N
CAS Number
CAS 152302-33-5
PubChem Compound ID
127856
PubChem Substance ID
10241875, 14823526, 29307040, 57342350, 58107147, 76204003, 85209277, 95469114, 103173960, 103968097, 104366785, 123496275, 125718450, 127972839, 130306715, 135082446, 135650963, 142374842, 162402910, 162795708, 166929854, 180335512, 225013919, 231995768
Target and Pathway
Target(s) Melatonin receptor Target Info Modulator [534707]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 538838(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1360).
Ref 546213Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006913)
Ref 534707Effects of two melatonin analogues, S-20098 and S-20928, on melatonin receptors in the pars tuberalis of the rat. J Pineal Res. 1998 Oct;25(3):172-6.

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