Drug Information

Drug General Information
Drug ID
D0Q7SO
Former ID
DIB016391
Drug Name
RS-66252
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Terminated [546339]
Company
Roche Bioscience
Canonical SMILES
c1(c(n(c2c1cccc2)CCCC)Cc1ccc(c2c(c3nnn[nH]3)cccc2)cc1)C<br />(=O)O
CAS Number
CAS 149652-34-6
Target and Pathway
Target(s) Type-1 angiotensin II receptor Target Info Modulator [551841]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Renin-angiotensin system
Renin secretion
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway Angiotensin Metabolism
Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Allograft Rejection
GPCR ligand binding
GPCR downstream signaling
References
Ref 546339Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007561)
Ref 551841Virtual Screening in Drug Discovery, Juan Alvarez Brian Shoichet. Page(218).

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