Drug Information

Drug General Information
Drug ID
D01SWK
Former ID
DIB016776
Drug Name
Rafabegron
Synonyms
AD-9677; AJ-9677; TAK-677
Drug Type
Small molecular drug
Indication Type 2 diabetes [ICD9: 250; ICD10:E11] Discontinued in Phase 2 [546607]
Company
Dainippon Pharmaceutical Co Ltd
Formula
C21H23ClN2O4
Canonical SMILES
c12c(c(c[nH]2)C[C@H](NC[C@@H](c2cc(ccc2)Cl)O)C)cccc1OCC<br />(=O)O
CAS Number
CAS 244081-42-3
PubChem Compound ID
5493324
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Modulator [528534]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 546607Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009164)
Ref 528534Lack of an effect of a novel beta3-adrenoceptor agonist, TAK-677, on energy metabolism in obese individuals: a double-blind, placebo-controlled randomized study. J Clin Endocrinol Metab. 2007 Feb;92(2):527-31. Epub 2006 Nov 21.

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