Drug Information

Drug General Information
Drug ID
D0T5SZ
Former ID
DIB000349
Drug Name
PNU-142721
Synonyms
PNU-109866; PNU-142721E
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Discontinued in Phase 1 [546794]
Company
Pharmacia & Upjohn Inc
Formula
C13H11ClN4OS
Canonical SMILES
c1(nc(cc(n1)Cl)N)S[C@H](c1ncc2c(c1)cco2)C
CAS Number
CAS 185220-03-5
PubChem Compound ID
446309
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Inhibitor [531587]
References
Ref 546794Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010327)
Ref 531587Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721. Protein Sci. 2011 Oct;20(10):1713-9.

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