Drug Information

Drug General Information
Drug ID
D03DRR
Former ID
DIB011193
Drug Name
Noberastine
Synonyms
Flamizole; R-64947; R-72075
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 2 [544807]
Company
Janssen Pharmaceutica NV
Formula
C17H21N5O
Canonical SMILES
n1(c(nc2c1nccc2)NC1CCNCC1)Cc1oc(cc1)C
CAS Number
CAS 110588-56-2
PubChem Compound ID
60531
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [528242]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 544807Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001178)
Ref 528242A double-blind placebo controlled dose response study of noberastine on histamine induced weal and flare. Eur J Clin Pharmacol. 1991;40(1):83-5.

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