Drug Information

Drug General Information
Drug ID
D0N7QP
Former ID
DIB006713
Drug Name
NO-antihypertensives
Synonyms
NCX-899; NCX-900; NO donor ACE inhibitors (hypertension), NicOx/Merck & Co; NO-antihypertensives, NicOx/Merck & Co; NO-enalapril (hypertension), NicOx/Merck & Co
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Terminated [546899]
Company
NicOx SA
Canonical SMILES
N1(C(=O)[C@@H](N[C@H](C(=O)OCC)CCc2ccccc2)C)[C@H](C(=O)<br />OCCCO[N+](=O)[O-])CCC1.C(=C\C(=O)O)\C(=O)O
Target and Pathway
Target(s) Angiotensin-converting enzyme Target Info Inhibitor [544048]
KEGG Pathway Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 546899Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010971)
Ref 544048Molecular determinants of cAMP-mediated regulation of the Na+-Ca2+ exchanger expressed in human cell lines. J Physiol. 2003 May 1; 548(Pt 3): 677-689.

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