Drug Information

Drug General Information
Drug ID
D03WPI
Former ID
DIB001826
Drug Name
NC-190
Synonyms
NCU-190Na
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 2 [544763]
Company
Taisho Pharmaceutical Co Ltd
Formula
C23H21N4NaO5
Canonical SMILES
c12c(c(c(c3c1cccc3)O)C(=O)NCCN(C)C)nc1c(n2)cc(c(c1)C(=O<br />)[O-])OC.[Na+]
PubChem Compound ID
23663980
Target and Pathway
Target(s) DNA topoisomerase II Target Info Modulator [526888]
References
Ref 544763Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000904)
Ref 526888The topoisomerase II-inhibitor NC-190 reduces the level of thymidine kinase mRNA in murine tumor cells. Res Commun Mol Pathol Pharmacol. 2002;111(1-4):77-87.

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