Drug Information

Drug General Information
Drug ID
D0L0UF
Former ID
DIB009434
Drug Name
MEN-11467
Indication Respiratory tract inflammation [ICD10:J00-J99] Terminated [546840]
Company
The Menarini Group
Canonical SMILES
c1(C(=O)N[C@@H]2[C@H](NC(=O)[C@H](N(C(=O)Cc3ccc(cc3)C)C<br />)Cc3cc4c(cc3)cccc4)CCCC2)c[nH]c2c1cccc2
CAS Number
CAS 214487-46-4
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [525953]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 546840Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010564)
Ref 525953Effect of the long-acting tachykinin NK(1) receptor antagonist MEN 11467 on tracheal mucus secretion in allergic ferrets. Br J Pharmacol. 2001 Jan;132(1):189-96.

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