Drug Information

Drug General Information
Drug ID
D0L5BK
Former ID
DIB008931
Drug Name
KW-2149
Synonyms
KT-6149; E-90/007; Mitomycin C derivatives (cancer), Kyowa
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 3 [545214]
Company
Kyowa Hakko Kogyo Co Ltd
Formula
C24H34N6O8S2
Canonical SMILES
[C@@]12([C@H]3N[C@H]3CN1C1=C([C@H]2COC(=O)N)C(=O)C(=C(C<br />1=O)C)NCCSSCCNC(=O)CC[C@@H](C(=O)O)N)OC
CAS Number
CAS 118359-59-4
PubChem Compound ID
108151
Target and Pathway
Target(s) Human DNA Target Info Binder [534691]
References
Ref 545214Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002474)
Ref 534691KW-2149 (7-N-[2-[gamma-L-glutamylamino]ethyldithioethyl] mitomycin C): DNA interactions and drug uptake following serum activation. Biochem Pharmacol. 1998 Jun 1;55(11):1777-83.

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