Drug Information

Drug General Information
Drug ID
D0J2NB
Former ID
DIB008260
Drug Name
KRH-594
Synonyms
KRG-594; WK-1492; WK-1492-2K
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Discontinued in Phase 2 [546398]
Company
Wakunaga Pharmaceutical Co Ltd
Formula
C25H22KN7O3S
Canonical SMILES
c1(c(c2[n-]nnn2)cccc1)c1ccc(cc1)Cn1/c(=N/C(=O)C2=C(CCC2<br />)C(=O)[O-])/sc(n1)CC.[K+].[K+]
CAS Number
CAS 169328-25-0
PubChem Compound ID
23703120
Target and Pathway
Target(s) Type-1 angiotensin II receptor Target Info Antagonist [526535]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Renin-angiotensin system
Renin secretion
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway Angiotensin Metabolism
Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Allograft Rejection
GPCR ligand binding
GPCR downstream signaling
References
Ref 546398Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007913)
Ref 526535Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors. Fundam Clin Pharmacol. 2002 Aug;16(4):317-23.

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