Drug Information

Drug General Information
Drug ID
D06WOJ
Former ID
DIB002559
Drug Name
JTH-601
Synonyms
JTH-601-G-1
Indication Prostate disease [ICD10:N42.9] Discontinued in Phase 2 [546856]
Company
Japan Tobacco Inc
Canonical SMILES
c1(c(c(c(c(c1C)O)C)C)OC)CN(CCOc1c(cc(c(c1)C)O)C(C)C)C.C<br />(=O)(/C=C/C(=O)O)O
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Antagonist [525752]
Alpha-2C adrenergic receptor Target Info Antagonist [525752]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04022:cGMP-PKG signaling pathway
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
References
Ref 546856Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010685)
Ref 525752Effect of JTH-601, a novel alpha(1)-adrenoceptor antagonist, on prostate function in dogs. Eur J Pharmacol. 2000 Apr 7;394(1):123-30.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.