Drug Information

Drug General Information
Drug ID
D09WCE
Former ID
DIB006068
Drug Name
IS-159
Drug Type
Small molecular drug
Indication Migraine [ICD9: 346; ICD10:G43] Discontinued in Phase 2 [545995]
Company
Immunotech SA
Formula
C23H27N5O5
Canonical SMILES
[nH]1cc(c2c1ccc(c2)OCC(=O)N[C@H](C(=O)NCC(=O)N)Cc1ccc(c<br />c1)O)CCN
CAS Number
CAS 133790-13-3
PubChem Compound ID
196859
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Modulator
5-hydroxytryptamine 1D receptor Target Info Modulator
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 545995Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005786)

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.