Drug Information

Drug General Information
Drug ID
D0M7BW
Former ID
DIB004618
Drug Name
GR-89696
Synonyms
GR-103545; 1-Piperazinecarboxylic acid, 4-[(3,4-dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-, methyl ester
Drug Type
Small molecular drug
Indication Neurodegenerative disease [ICD9: 330-337; ICD10:G30-G32] Terminated [539020], [545442]
Company
Glaxo Group Research Ltd
Formula
C19H25Cl2N3O3
InChI
InChI=1S/C19H25Cl2N3O3/c1-27-19(26)23-8-9-24(15(13-23)12-22-6-2-3-7-22)18(25)11-14-4-5-16(20)17(21)10-14/h4-5,10,15H,2-3,6-9,11-13H2,1H3
InChIKey
HJUAKZYKCANOOZ-UHFFFAOYSA-N
PubChem Compound ID
3505
PubChem Substance ID
7351428, 8152226, 14929026, 26752200, 29222637, 47810986, 50104864, 80164383, 85211665, 85787610, 90341533, 103976278, 104303710, 124749821, 124880191, 124880192, 126407629, 128071019, 135650321, 137146567, 140555113, 143122030, 162221929, 162967793, 179149751, 179554151, 230465052, 242084400
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Modulator [526244]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539020(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1649).
Ref 545442Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003263)
Ref 526244[(11)C]-GR89696, a potent kappa opiate receptor radioligand; in vivo binding of the R and S enantiomers. Nucl Med Biol. 2002 Jan;29(1):47-53.

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