Drug Information

Drug General Information
Drug ID
D0ZE5V
Former ID
DIB010354
Drug Name
FPL-55712
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Terminated [544540]
Company
Fisons plc
Formula
C27H29NaO9
Canonical SMILES
c12c(c(ccc1c(=O)cc(o2)C(=O)[O-])OCC(COc1c(c(c(cc1)C(=O)<br />C)O)CCC)O)CCC.[Na+]
CAS Number
CAS 40786-08-1
PubChem Compound ID
23662025
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Modulator [529534]
Leukotriene CysLT2 receptor Target Info Modulator [529534]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling PathwayNetPath_16:IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelinsendothelinpathway:Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 544540Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000089)
Ref 529534Effect of the leukotriene receptor antagonists FPL 55712, LY 163443, and MK-571 on the elimination of cysteinyl leukotrienes in the rat. Br J Pharmacol. 1991 Apr;102(4):865-70.

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