Drug Information

Drug General Information
Drug ID
D0BN4Y
Former ID
DIB014567
Drug Name
Ebalzotan
Synonyms
NAE-086
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Discontinued in Phase 1 [546211]
Company
Astra AB
Formula
C19H30N2O2
Canonical SMILES
C(=O)(c1c2C[C@@H](N(C(C)C)CCC)COc2ccc1)NC(C)C
CAS Number
CAS 149494-37-1
PubChem Compound ID
9797080
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [526199]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 546211Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006909)
Ref 526199The pharmacological profile of (R)-3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide, a selective 5-hydroxytryptamine(1A) receptor agonist. J Pharmacol Exp Ther. 2001 Dec;299(3):883-93.

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