Drug Information

Drug General Information
Drug ID
D06UVO
Former ID
DIB014433
Drug Name
DuP-654
Drug Type
Small molecular drug
Indication Pruritus [ICD9: 698; ICD10:L29] Discontinued in Phase 2 [545553]
Company
Bristol-Myers Squibb Pharma Co
Formula
C17H14O
Canonical SMILES
c1(c(Cc2ccccc2)ccc2c1cccc2)O
CAS Number
CAS 36441-32-4
PubChem Compound ID
160268
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [534020]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 545553Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003690)
Ref 534020The lipoxygenase inhibitor 2-phenylmethyl-1-naphthol (DuP 654) is a 12(S)-hydroxyeicosatetraenoic acid receptor antagonist in the human epidermal cell line SCL-II. Skin Pharmacol. 1993;6(2):148-51.

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