Drug Information

Drug General Information
Drug ID
D0RJ6R
Former ID
DIB003815
Drug Name
Du-123015
Synonyms
Benzopyran piperazine derivative (5HT modulator, neurological disorders), Solvay
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Terminated [550366]
Company
Solvay SA
Canonical SMILES
c1(=O)oc2c(cc1N)cccc2N1CCNCC1.Cl.O
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Modulator [550367]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 550366Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT1A agonist in rat models of ischaemic stroke. BMC Neuroscience 2009, 10:82.
Ref 550367Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT1A agonist in rat models of ischaemic stroke. BMC Neuroscience 2009, 10:82.

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