Drug Information

Drug General Information
Drug ID
D06FCR
Former ID
DIB000982
Drug Name
CL-277082
Drug Type
Small molecular drug
Indication Arteriosclerosis [ICD9: 440; ICD10:I70] Discontinued in Phase 1 [544948]
Company
Lederle Laboratories
Formula
C26H36F2N2O
Canonical SMILES
C(=O)(Nc1c(cc(cc1)F)F)N(Cc1ccc(CC(C)(C)C)cc1)CCCCCCC
CAS Number
CAS 96224-26-9
PubChem Compound ID
125893
Target and Pathway
Target(s) Liver carboxylesterase Target Info Modulator [533344]
KEGG Pathway Drug metabolism - other enzymes
Metabolic pathways
Pathway Interaction Database E2F transcription factor network
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Heroin metabolism
Irinotecan Pathway
Fluoropyrimidine Activity
Phase I biotransformations, non P450
References
Ref 544948Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001648)
Ref 533344CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption. J Lipid Res. 1989 May;30(5):681-90.

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