Drug Information

Drug General Information
Drug ID
D0PG0S
Former ID
DIB016093
Drug Name
CI-999
Synonyms
PD-138142-15
Indication Arteriosclerosis [ICD9: 440; ICD10:I70] Terminated [546902]
Company
Warner-Lambert Co
Canonical SMILES
c1(c(cccc1C(C)C)C(C)C)OS(=O)(=O)[N-]C(=O)Oc1c(cccc1C(C)<br />C)C(C)C.[Na+]
Target and Pathway
Target(s) Liver carboxylesterase Target Info Inhibitor [534786]
KEGG Pathway Drug metabolism - other enzymes
Metabolic pathways
Pathway Interaction Database E2F transcription factor network
WikiPathways NRF2 pathway
Nuclear Receptors Meta-Pathway
Heroin metabolism
Irinotecan Pathway
Fluoropyrimidine Activity
Phase I biotransformations, non P450
References
Ref 546902Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010990)
Ref 534786Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates. Bioorg Med Chem Lett. 1998 Feb 3;8(3):289-94.

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