Drug Information

Drug General Information
Drug ID
D0R1VL
Former ID
DIB008949
Drug Name
BIBN-99
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Terminated [545083]
Company
Boehringer Ingelheim Corp
Formula
C31H42ClN5O3
Canonical SMILES
n1(c2c(c(=O)[nH]c3c1nccc3)cc(cc2)Cl)C(=O)CN1CCC(CC1)CCC<br />N(C(=O)C(CCC)(C)C)CC
CAS Number
CAS 145301-48-0
PubChem Compound ID
132712
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M2 Target Info Modulator [533931]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling events
WikiPathways SIDS Susceptibility Pathways
Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 545083Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002066)
Ref 533931Characterization of BIBN 99: a lipophilic and selective muscarinic M2 receptor antagonist. Eur J Pharmacol. 1993 Sep 21;242(1):23-30.

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