Drug Information

Drug General Information
Drug ID
D04DQZ
Former ID
DIB010761
Drug Name
AZD-2327
Synonyms
Opioid receptor delta agonist (anxiety, depression), AstraZeneca
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Phase 2 [522445]
Company
AstraZeneca plc
Formula
C29H35FN4O
Canonical SMILES
c1(ccc(cc1)[C@@H](N1CCN(CC1)Cc1ccc(cc1)F)c1cc(ccc1)N)C(<br />=O)N(CC)CC
PubChem Compound ID
11525765
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Agonist [531414]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 522445ClinicalTrials.gov (NCT00759395) Study of Antidepressant Efficacy of a Selective, High Affinity Enkephalinergic Agonist in Anxious Major Depressive Disorder (AMDD). U.S. National Institutes of Health.
Ref 531414Preclinical pharmacology of AZD2327: a highly selective agonist of the delta-opioid receptor. J Pharmacol Exp Ther. 2011 Jul;338(1):195-204.

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