Drug Information

Drug General Information
Drug ID
D08RMH
Former ID
DIB013841
Drug Name
APC-2059
Synonyms
BAY-44-3965
Indication Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51] Discontinued in Phase 2 [546785]
Company
Celera South San Francisco
Canonical SMILES
[C@@H]12[C@H](OC[C@H]2OC(=O)N2CCN(C(=O)NCc3ccc(NC(=N)N)<br />cc3)CC2)[C@H](OC(=O)N2CCN(C(=O)NCc3ccc(NC(=N)N)cc3)CC2)<br />CO1
Target and Pathway
Target(s) Tryptase Target Info Inhibitor [526283]
Reactome Activation of Matrix Metalloproteinases
References
Ref 546785Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010270)
Ref 526283Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Aliment Pharmacol Ther. 2002 Mar;16(3):407-13.

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